JSM 2011 Online Program

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Abstract Details

Activity Number: 330
Type: Topic Contributed
Date/Time: Tuesday, August 2, 2011 : 10:30 AM to 12:20 PM
Sponsor: Biometrics Section
Abstract - #303248
Title: Biomarker Study Under Nested Case-Control Design
Author(s): Yingye Zheng*+ and Tianxi Cai
Companies: Fred Hutchinson Cancer Research Center and Harvard University
Address: 1100 Fairview Ave. NE, Seattle , WA, 98109,
Keywords:
Abstract:

Nested case-control design provides a cost-effective cohort sampling strategy in biomarker research. We propose estimating procedures to evaluate the prognostic accuracy of a novel biomarker for predicting future events with censored failure time outcome under a matched nested case-control design. In the presence of missing information on the biomarker measurements, we develop consistent estimators for time-dependent classification and predictive accuracy measures based on the idea of inverse probability weighting.


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