JSM 2011 Online Program

The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.

Abstract Details

Activity Number: 649
Type: Topic Contributed
Date/Time: Thursday, August 4, 2011 : 10:30 AM to 12:20 PM
Sponsor: Section on Nonparametric Statistics
Abstract - #303070
Title: Joint and Individual Variation Explained (JIVE) for Integrated Analysis of Multiple Datatypes
Author(s): Eric Frazer Lock*+
Companies: The University of North Carolina at Chapel Hill
Address: 107 West Main St., Carrboro, NC, 27510,
Keywords: Multi-block data ; Data integration ; Principal Component Analysis
Abstract:

Research in several fields now requires the analysis of "multi- block" data, in which multiple high-dimensional and fundamentally disparate datatypes are available for a common set of objects. In this paper we introduce Joint and Individual Variation Explained (JIVE), a general method for the integrated analysis of multi-block data. The method decomposes a multi-block dataset into a sum of three terms: a low-rank approximation capturing joint variation between datatypes, a low-rank approximation for structured variation individual to each datatype, and residual noise. This decomposition can be used to quantify the amount of joint variation between datatypes, visually explore joint and individual structure, and reduce the dimensionality of the data. The proposed method represents an extension of Principal Component Analysis (PCA) and has clear advantages over popular two-block methods such as Canonical Correlation Analysis (CCA) and Partial Least Squares (PLS). We apply JIVE to data from The Cancer Genome Atlas (TCGA), where multiple genomic technologies are available for a common set of Glioblastoma Multiforme tumor samples.


The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.

Back to the full JSM 2011 program




2011 JSM Online Program Home

For information, contact jsm@amstat.org or phone (888) 231-3473.

If you have questions about the Continuing Education program, please contact the Education Department.