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Abstract Details
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Activity Number:
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423
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Type:
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Contributed
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Date/Time:
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Tuesday, August 2, 2011 : 2:00 PM to 3:50 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #303038 |
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Title:
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Subgroup Discovery Showing Maximum Difference Between Treatment and Control Using Modified Patient Rule Induction Method (M-PRIM)
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Author(s):
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Daniel Parks*+ and Xiwu Lin and Kwan Lee
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Companies:
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GlaxoSmithKline and GlaxoSmithKline and GlaxoSmithKline
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Address:
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, , ,
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Keywords:
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PRIM ;
M-PRIM ;
Subgroup
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Abstract:
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Identifying patient subgroups that show discernable differences in treatment effectiveness and/or safety profiles based on demographic and baseline variables is of major interest to clinicians and patients. In this work, we have extended the capability of the Patient Rule Induction method (PRIM) to automatically handle the important application of searching for subgroups that have large difference in treatment effectiveness when two treatments are compared. Comparison to other related methods and the limitations of the proposed method will also be discussed. Simulations and analysis of an actual clinical trial data will be shown to illustrate the proposed method.
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