JSM 2011 Online Program

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Abstract Details

Activity Number: 185
Type: Contributed
Date/Time: Monday, August 1, 2011 : 10:30 AM to 12:20 PM
Sponsor: Section on Statistics in Epidemiology
Abstract - #302755
Title: Assessing the Health Impact of Multiple Environmental Chemicals: PCBs and Hypertension in the National Health and Nutrition Examination Survey
Author(s): Krista Christensen*+ and Paul White
Companies: Environmental Protection Agency and Environmental Protection Agency
Address: , , 20460,
Keywords: Hypertension ; PCBs ; NHANES

Classical epidemiological methods may not be suitable for evaluation of complex exposures. We used data from the 1999-2004 National Health and Nutrition Examination Survey to illustrate an approach to complex exposures, using as our example the association between serum PCB levels and risk of hypertension. First, unconditional logistic regression was used to estimate odds ratios (ORs) and associated 95% confidence intervals (CIs), controlling for potential confounding covariates. Next, correlation and multicollinearity among PCB congeners was evaluated, and clustering analyses performed to determine groups of related congeners. Finally, an optimally weighted sum was constructed to represent the relative strength of association for each congener. PCB serum concentrations were on average higher among those with hypertension. However, multivariate analyses showed mixed findings; total PCBs

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