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Abstract Details
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Activity Number:
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330
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Type:
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Topic Contributed
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Date/Time:
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Tuesday, August 2, 2011 : 10:30 AM to 12:20 PM
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Sponsor:
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Biometrics Section
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| Abstract - #302537 |
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Title:
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Efficiency Loss When Using Frequency Matching and Balance as Design Strategies in Case-Control and Two-Phase Studies
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Author(s):
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Alan J. Lee*+ and Jennifer L. Wilcock
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Companies:
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University of Auckland and University of Auckland
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Address:
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Department of Statistics, Auckland, International, 1142, New Zealand
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Keywords:
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Balanced design ;
Frequency matching ;
Two-stage design ;
Optimal design ;
case-control
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Abstract:
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Frequency matching is a common design strategy aimed at improving the efficiency of case-control studies, while the use of balanced designs is a similar strategy in the case of two-phase designs. In this paper, we examine the efficiency loss (compared to the theoretical optimal design) when pursuing these strategies. We assume that estimation is done using the semi-parametric method of Scott and Wild (Scott and Wild, Biometrika,1997), and develop an asymptotic formula for the variance of the estimator in both these designs. This is used to find optimal designs and hence compute the efficiency loss. Some extensions to related situations such as multistage designs are considered.
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