JSM 2011 Online Program

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Abstract Details

Activity Number: 220
Type: Topic Contributed
Date/Time: Monday, August 1, 2011 : 2:00 PM to 3:50 PM
Sponsor: Section on Statistical Consulting
Abstract - #302509
Title: Statistical Pharmacogenomics Studies in Data Services CRO and Biotech
Author(s): Kit Lau*+
Companies: i3 Statprobe
Address: 39120 Argonaut Way #568, Fremont, CA, 94538,
Keywords: consulting ; service ; pharmacogenomics ; CRO ; biotech
Abstract:

Pharmacogenomics (PGx) studies to elucidate biomarkers to predict therapy response and safety are becoming an integral part of clinical trials. The potential of having genomic biomarkers to help tailor therapies for individuals and to predict prognosis is being realized. However, significant challenges in study design and statistical analyses in genomic data remain important road blocks to the success in the field. Statistical learning, data mining methods together with classical statistical techniques to analyze genomic data for clinical utilities would be illustrated, using examples of genetic and genomic studies to elucidate genetic association with drug response and prognostic signature in Neurosciences and Oncology. Through these examples, triumphs and tribulations of working as a CRO statistician in a strategic alliance with big pharmaceutical companies would also be discussed.


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