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Abstract Details
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Activity Number:
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667
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Type:
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Contributed
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Date/Time:
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Thursday, August 4, 2011 : 10:30 AM to 12:20 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #302451 |
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Title:
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Confounding Issues Originated from Clinical Trials
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Author(s):
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Junshan Qiu*+
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Companies:
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U.S. Food and Drug Administration
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Address:
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7500 standish place, Rockville, MD, 20855,
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Keywords:
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Confounding variables ;
Type I error ;
Power
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Abstract:
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A poorly designed experiment usually ends up with confounding variables. It is well recognized that confounding variables have a variety of unignorable impacts on interpretation of study results. Particularly, the impact on efficiency of testing primary endpoints is a big concern. Simulation studies are used to investigate the underlying contributing factors related to the impacts concerned such as type I error rate and power. A definition of extent of confounding was proposed. How the extent of confounding affects model structures was investigated and further discussed regarding balancing Type I error and power.
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The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
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