JSM 2011 Online Program

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Abstract Details

Activity Number: 404
Type: Contributed
Date/Time: Tuesday, August 2, 2011 : 2:00 PM to 3:50 PM
Sponsor: Biometrics Section
Abstract - #302388
Title: Signals to be Seen in Tiled Microarray Experiments
Author(s): Sigrun Helga Lund*+ and Gunnar Stefansson
Companies: University of Iceland and University of Iceland
Address: Dunhagi 5, Reykjavik, 107, Iceland
Keywords: tiled microarray ; isothermal probes ; repeated probes ; false positive ; power

The accuracy of signals obtained from tiled microarray experiments has been debated. In this paper four types of signals to be seen in tiled microarray experiments are defined and their replicability tested in three sets of experiments, containing the same samples, but the probesets varying from isothermal probes to probes of equal lengths. The third experiment included repeated copies of each probe which allowed the power of each type of signal to be estimated, both within and between samples. The probability of both false positive and false negative signals for each of the four types was also estimated.

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