The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.
Abstract Details
|
Activity Number:
|
14
|
|
Type:
|
Topic Contributed
|
|
Date/Time:
|
Sunday, July 31, 2011 : 2:00 PM to 3:50 PM
|
|
Sponsor:
|
International Chinese Statistical Association
|
| Abstract - #302365 |
|
Title:
|
Inference in Designs with Interim Treatment Selection by a Flexible Selection Margin
|
|
Author(s):
|
Yujun Wu*+ and Yunwen Yang and Peng-liang Zhao
|
|
Companies:
|
sanofi-aventis and University of Illinois at Urbana-Champaign and sanofi-aventis
|
|
Address:
|
15 McElroy Ln, Belle Mead, NJ, 08502, USA
|
|
Keywords:
|
adaptive design ;
interim treatment selection ;
estimation ;
clinical trials
|
|
Abstract:
|
A two-stage adaptive design with selection of the treatments at the interim stage has been introduced by Wu and Zhao (2009). The design specifies a selection margin which is used to define the acceptable interim treatment effects for further consideration. On one hand, this margin allows the selection of more than one arm at the interim stage; on the other hand, it plays as a futility rule to stop the treatment arms with significantly inferior effect when compared to the arm with the highest mean response. Statistical inference including hypothesis testing and point estimation are discussed for the general cases with no limitations on the number of treatment arms in the study. The case with binary endpoint is also discussed.
|
The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
Back to the full JSM 2011 program
|
2011 JSM Online Program Home
For information, contact jsm@amstat.org or phone (888) 231-3473.
If you have questions about the Continuing Education program, please contact the Education Department.