JSM 2011 Online Program

The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.

Abstract Details

Activity Number: 190
Type: Contributed
Date/Time: Monday, August 1, 2011 : 10:30 AM to 12:20 PM
Sponsor: Section on Statistics in Epidemiology
Abstract - #302273
Title: Comparing Splines and Fractional Polynomials in Modeling Time-to-Event Data
Author(s): Leila D. Amorim*+ and NĂ­vea B. Silva
Companies: Federal University of Bahia and Federal University of Minas Gerais
Address: Rua Joaquim Ferraro do Nascimento, 102, apto.1003,, Salvador-Bahia, International, 41830-440, Brazil
Keywords: splines ; fractional polynomials ; cox model ; time-to-event data ; survival analysis

Smoothing approaches have become increasily popular in applied research, particularly due to their flexibility to model the functional form of continuous covariate's effect on an outcome. Splines methods and fractional polynomials have extensively been used in various applications. Research has been conducted for evaluating the performance of such approaches on the fit of generalized linear models and Cox models. However, comparison between the smoothing approaches in the context of analyzing time-to-event data is still limited. We compared regression splines and smoothing splines, which are techniques that differ in the number of knots used, in the way of determining their positions and on how the parameters for the polynomial pieces are estimated, to the fractional polynomials. These approaches are applied to the analysis of diarrhea time-to-event data. Simulation studies examined the strengths and weakness of different smoothing approaches.

The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.

Back to the full JSM 2011 program

2011 JSM Online Program Home

For information, contact jsm@amstat.org or phone (888) 231-3473.

If you have questions about the Continuing Education program, please contact the Education Department.