The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.
Abstract Details
|
Activity Number:
|
116
|
|
Type:
|
Topic Contributed
|
|
Date/Time:
|
Monday, August 1, 2011 : 8:30 AM to 10:20 AM
|
|
Sponsor:
|
Biopharmaceutical Section
|
| Abstract - #301636 |
|
Title:
|
Binomial Confidence Intervals for Testing Noninferiority or Superiority: A Practitioner's Dilemma
|
|
Author(s):
|
Vivek Pradhan*+ and John C Evans and Tathagata Banerjee
|
|
Companies:
|
Boston Scientific Corporation and Boston Scientific Corporation and IIMA
|
|
Address:
|
, , 01752, USA
|
|
Keywords:
|
coverage ;
expected length ;
location ;
non-inferiority ;
superiority
|
|
Abstract:
|
In testing for non-inferiority or superiority in a single arm study, the confidence interval of a single binomial proportion is frequently used. There are several intervals available in the literature, and most of them can be implemented using available software packages. In carrying out these tests, practitioners often face the serious problem that, different intervals may lead to conflicting conclusions, regarding acceptance or rejection of the null hypothesis. We address this question by investigating the performances of nine commonly used intervals of a single binomial proportion, in the light of three criteria, viz., coverage, expected length and location of the interval. An example with device trial data is presented.
|
The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
Back to the full JSM 2011 program
|
2011 JSM Online Program Home
For information, contact jsm@amstat.org or phone (888) 231-3473.
If you have questions about the Continuing Education program, please contact the Education Department.