The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.
Abstract Details
|
Activity Number:
|
626
|
|
Type:
|
Contributed
|
|
Date/Time:
|
Thursday, August 4, 2011 : 8:30 AM to 10:20 AM
|
|
Sponsor:
|
Biopharmaceutical Section
|
| Abstract - #301341 |
|
Title:
|
Estimation of the Competing Probability for the Van Elteren Test
|
|
Author(s):
|
Yan Daniel Zhao*+ and Dewi Gabriela Rahardja and Alex Dmitrienko
|
|
Companies:
|
The University of Texas Southwestern Medical Center and The University of Texas Southwestern Medical Center and Eli Lilly and Company
|
|
Address:
|
, , TX, , USA
|
|
Keywords:
|
Clinical trial ;
competing probability ;
confidence interval ;
statistical inference ;
van Elteren test
|
|
Abstract:
|
The van Elteren (vE) test, a stratified Wilcoxon-Mann-Whitney test, is a widely used nonparametric method for comparing two treatments adjusting for stratum effects. Although the vE test produces a p-value for testing the null hypothesis of no treatment effect, additional heuristic methods need to be used to determine which treatment is better. Moreover, such heuristic methods may lead to inconclusive decisions in some situations. Furthermore, it is unclear on how to quantify treatment effect size when the van Elteren test is used. In this paper, we define a competing probability (CP) inherently related to the vE test and derive point and interval estimators for CP. The CP serves as an effect size measure and can be used to determine which treatment is better by comparing the CP with 0.
|
The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
Back to the full JSM 2011 program
|
2011 JSM Online Program Home
For information, contact jsm@amstat.org or phone (888) 231-3473.
If you have questions about the Continuing Education program, please contact the Education Department.