Population-Based Screening for Prostate Cancer: Improved Outcomes in African-American Men

• Activity Number: 38
• Type: Contributed
• Date/Time: Sunday, July 31, 2011 : 2:00 PM to 3:50 PM
• Sponsor: ENAR
• Author(s): Yuanyuan Liang*+ and Donna P. Ankerst and Norma S. Ketchum and Robin J. Leach and Ian M. Thompson and Brad H. Pollock
• Companies: The University of Texas Health Science Center at San Antonio and Technical University and The University of Texas Health Science Center at San Antonio and The University of Texas Health Science Center at San Antonio and The University of Texas Health Science Center at San Antonio and The University of Texas Health Science Center at San Antonio
• Keywords: Prostate Cancer ; PCPT Risk Calculator ; ethnicity ; body mass index

Abstract

African American men have a higher incidence of prostate cancer (PCa) and are more likely to die from the disease than men of other races. PCa incidence is lower in Hispanics but the stage of the disease is more advanced at the time of diagnosis. Our study examined how racial diversity uniquely affects PCa screening while accounting for body mass index (BMI) using a population-based prospectively collected San Antonio center for Biomarkers Of Risk for prostate cancer (SABOR) cohort. Area under the receiver operating characteristic curves of prostate-specific antigen (PSA), BMI-adjusted PSA, Prostate Cancer Prevention Trial (PCPT) PCa risk and high-grade PCa (Gleason score = 7) risk, and BMI-adjusted PCPT risks were compared among different ethnic groups. Our study found that, in this SABOR cohort, the original and BMI-adjusted PCPT risk calculators performed significantly better for PCa detection than PSA alone for Hispanics and non-Hispanic whites. All screening modalities, including PSA, performed markedly better for African Americans than for other race/ethnic groups.