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Abstract Details
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Activity Number:
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414
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Type:
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Contributed
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Date/Time:
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Tuesday, August 2, 2011 : 2:00 PM to 3:50 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #300525 |
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Title:
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Analysis of Drug Effect on Counts of Lymphocyte Subsets
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Author(s):
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Jiacheng Yuan*+
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Companies:
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Astellas Pharma Global Development, Inc.
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Address:
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3 Parkway North, Deerfield, IL, 60015, USA
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Keywords:
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Bayesian method ;
clinical study ;
CD antigen ;
MCMC ;
total lymphocyte count
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Abstract:
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A Bayesian analysis method with MCMC sampling is suggested to analyze the counts of subsets of the total lymphocytes collected in clinical studies using the software WinBugs. Two major assumptions are made: (1) the count of lymphocytes with a set of antigens is the product of the total lymphocyte count (TLC), the set of proportions corresponding to lymphocytes with every individual antigens, and a multiplier for the interaction among the set of antigens under consideration; and (2) the drug effect impacts the TLC, as well as the proportions of cells with specific antigens. The analysis model also accounts for the positive correlation of changes from baseline of the same endpoint between two post-dose time points.
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The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
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