The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.
Abstract Details
|
Activity Number:
|
142
|
|
Type:
|
Invited
|
|
Date/Time:
|
Monday, August 1, 2011 : 10:30 AM to 12:20 PM
|
|
Sponsor:
|
ENAR
|
| Abstract - #300483 |
|
Title:
|
Testing Gene-by-Environment Interactions in Behavior Genetic Designs
|
|
Author(s):
|
Paul Rathouz*+ and Carol Van Hulle and Qianying Liu
|
|
Companies:
|
University of Wisconsin and University of Wisconsin and The University of Chicago
|
|
Address:
|
Dept of Biostatistics and Medical Informatics, Madison, WI, 53792,
|
|
Keywords:
|
|
|
Abstract:
|
Investigators in the field of behavior genetics exploit twin and other family designs in order to decompose phenotypic variance into components that are due to aggregate genetic factors and those that are due to aggregate environmental factors. Multivariate methods have allowed for the examination of the degree of overlap in genetic and/or environmental contributions between two or more phenotypes. Newer non-linear structural models have attempted to extend these models in order to quantify gene-by-environmental (GxE) interactions wherein the focus is on specific environmental or pre-disposing factors, and their potentially synergistic effects with aggregate genetic effects. Motivated by problems in developmental psychopathology, we critically examine the statistical performance of these GxE methods with respect to model identifiability and power. We also propose a graphical decomposition of variance that can be useful to display fitted model results.
|
The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
Back to the full JSM 2011 program
|
2011 JSM Online Program Home
For information, contact jsm@amstat.org or phone (888) 231-3473.
If you have questions about the Continuing Education program, please contact the Education Department.