Advances in Measurement Error Adjustment in Nutrition and Physical Activity Epidemiology

• Activity Number: 487
• Type: Invited
• Date/Time: Wednesday, August 3, 2011 : 10:30 AM to 12:20 PM
• Sponsor: Section on Statistics in Epidemiology
• Author(s): Ross L. Prentice*+
• Companies: Fred Hutchinson Cancer Research Center
• Keywords: measurement error ; nutrition ; physical activity ; regression calibration ; hazard ratio ; systematic bias

Abstract

On the Use of Biomarker Sub-Studies to Correct for Measurement Error in Nutrition and Physical Activity Epidemiology Ross l. Prentice Fred Hutchinson Cancer Research Center and University of Washington Biomarker studies of nutrient consumption and activity-related energy expenditure will be described.These include a Nutrient Biomarker Study among 544 postmenopausal women in the Women's Health Initiative Dietary Modification Trial, and 450 women in the WHI prospective cohort study.A doubly-labeled water(DLW)biomarker of energy consumption, a urinary nitrogen biomarker of protein consumption and a (0.9*DLW -resting energy expenditure) objective assessment of activity-related energy expenditure will be log-transformed and regressed on corresponding log(self-report consumption/activity estimates) and such study subject characteristics as body mass, age and ethnicity, to yield calibrated consumption/activity estimates. Disease association estimates will be shown to be quire different and stronge following biomarker calibration, for cancer and cardiovascular diseases. Ongoing work to develop additional nutitional biomarkers via a human feeding study will be briefly described.