The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.
Abstract Details
|
Activity Number:
|
277
|
|
Type:
|
Invited
|
|
Date/Time:
|
Tuesday, August 2, 2011 : 8:30 AM to 10:20 AM
|
|
Sponsor:
|
Biopharmaceutical Section
|
| Abstract - #300258 |
|
Title:
|
Testing Individual Hypothesis Marginally at 0.05 Without Inflation of the Family-Wise Error Rate
|
|
Author(s):
|
David Li*+
|
|
Companies:
|
Pfizer Inc.
|
|
Address:
|
, , ,
|
|
Keywords:
|
multiple testing ;
consonant tests ;
collective evidence ;
consistency
|
|
Abstract:
|
As a clinical trial statistician, I was challenged numerous times by the question "can we test each hypothesis at 0.05?" Being asked again and again, finally I started asking myself: Can we test each hypothesis at 0.05 and how? This presentation will provide an answer to the question by constructing consonant multiple testing procedures. The consonant requirement is relatively inconsequential in a clinical trial when multiple primary endpoints have low correlations (rho = 0.3). For other scenarios, a modified version is proposed. These procedures are particularly useful when the collective evidence across endpoints or consistency across endpoints is expected or required.
|
The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
Back to the full JSM 2011 program
|
2011 JSM Online Program Home
For information, contact jsm@amstat.org or phone (888) 231-3473.
If you have questions about the Continuing Education program, please contact the Education Department.