JSM 2011 Online Program

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Abstract Details

Activity Number: 275
Type: Invited
Date/Time: Tuesday, August 2, 2011 : 8:30 AM to 10:20 AM
Sponsor: ENAR
Abstract - #300211
Title: Genetic Association Studies Using Individual and Pooled Sequence Data
Author(s): Hongyu Zhao*+ and Joon Sang Lee
Companies: Yale University and Yale University
Address: 300 George Street, New Haven, CT, ,
Keywords: sequencing ; rare variants ; pooling ; association ; complex traits ; statistical genomics
Abstract:

Second generation sequencing technologies have great promises to identify and associated novel DNA variants with complex diseases. Because the data are extremely information rich yet still expensive to collect, the design and analysis of such data presents many statistical challenges. In this talk, we will discuss several issues encountered in our ongoing studies and describe how statistical principles can be applied to improve design efficiency and derive more robust and efficient statistical tests.


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