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Abstract Details
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Activity Number:
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553
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Type:
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Invited
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Date/Time:
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Wednesday, August 3, 2011 : 2:00 PM to 3:50 PM
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Sponsor:
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WNAR
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| Abstract - #300057 |
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Title:
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Modeling PK/PGx Data
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Author(s):
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Donatello Telesca*+ and Gary Rosner and Peter Mueller
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Companies:
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University of California at Los Angeles and The Johns Hopkins University and The University of Texas MD Anderson Cancer Center
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Address:
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Department of Biostatistics, Los Angeles, CA, 90095-1772, USA
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Keywords:
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Graphical Models ;
Pharmacokinetics ;
RJMCMC ;
SNPs
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Abstract:
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We describe a general framework for the exploration of the relationships between pharmacokinetic pathways and plymorphisms in genes associated with the metabolism of a compound of interest. We integrate a population pharmacokinetics model with a simple sampling model of genetic mutation via a conditional dependence prior. Significant interactions are selected allowing the parmacokinetic parameters to depend on gene sets of variable dimension. We discuss posterior inference and prediction based on MCMC simulation. Our model finds motivation in the study of a chemotherapeutic agent used in the treatment of various solid tumors.
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