This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.

Abstract Details

Activity Number: 345
Type: Contributed
Date/Time: Tuesday, August 3, 2010 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section
Abstract - #309302
Title: Sample-Size Calculation for Time-to-Event Outcome with Treatment Lag Effect
Author(s): Yulei Zhang*+ and Tai-Tsang Chen
Companies: Columbia University and Bristol-Myers Squibb/Columbia University
Address: 722 West 168th Street, 6th fl, New York, NY, 10032, USA
Keywords: sample size ; power function ; time-to-event ; treatment lag ; design comparison

We reviewed classical sample size determination methods as Freedman (1982) and Rubinstein, Gail and Santner (1981) for constant hazard ratio design. For non-constant hazard ratio design, we reviewd Lakatos' Markov method and treated it as our starting point.

To obtain sample size addressing more flexible follow up duration, treatment lag length, non-compliance pattern and abrupt treatment effect change, Lakatos' algorithm was modified. We also rewrote its SAS code with Proc IML to replace the older version of Proc Matrix. The power function along increasing number of events was obtained.

To illustrate how the treatment lag length influenced the power accumulation pattern, we compared the power functions with different treatment lag length designs. It helps us decide whether sample size is feasible in different scenario of treatment lag effect.

Numerical examples were provided.

The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.

Back to the full JSM 2010 program

2010 JSM Online Program Home

For information, contact or phone (888) 231-3473.

If you have questions about the Continuing Education program, please contact the Education Department.