This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.

Abstract Details

Activity Number: 406
Type: Contributed
Date/Time: Tuesday, August 3, 2010 : 2:00 PM to 3:50 PM
Sponsor: Biometrics Section
Abstract - #309287
Title: Integrating Methylation Sequencing Data from Multiple Platforms
Author(s): Adam B. Olshen*+ and Ting Wang and Joseph Costello
Companies: University of California, San Francisco and Washington University in St. Louis and University of California, San Francisco
Address: 1450 3rd Street, MC 0128, San Francisco, CA, 94158,
Keywords: methylation ; sequencing

Different methylation platforms produce different types of data. For instance, methyl-sensitive restriction enzymes (MRE) sequencing is restricted to fixed positions in the genome, while methylated DNA immunoprecipitation (MeDIP) sequencing can take place anywhere in the genome. We report here on statistical methods for integrating data from different platforms. Our insight is to reframe the integration problem as a classification problem. We develop classification methods appropriate both to the technologies and to the underlying biology. We validate our methods on gold standard data.

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