This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.

Abstract Details

Activity Number: 187
Type: Contributed
Date/Time: Monday, August 2, 2010 : 10:30 AM to 12:20 PM
Sponsor: ENAR
Abstract - #309059
Title: Achieving the Benefits of Both an Internal Pilot and Interim Analysis in Small Samples
Author(s): John A. Kairalla*+ and Keith E. Muller and Christopher S. Coffey
Companies: University of Florida and University of Florida and The University of Iowa
Address: PO Box 100177, Gainesville, FL, 32610,
Keywords: Adaptive designs ; Power ; Sample size re-estimation

An internal pilot with interim analysis (IPIA) design combines interim power analysis (an internal pilot) with interim data analysis (a two stage group-sequential design). We describe methods for a practical IPIA design that works well even in small sample studies. The design provides the flexibility and efficiency of both the internal pilot and group sequential by controlling power and sample size simultaneously rather than either alone. New IPIA results for Gaussian linear models are valuable for both small and large studies. Enumerations demonstrate that guaranteeing control of type I error rate requires some form of correction. A simple bounding method approximately controls the type I error rate across all possible population variance values with little cost in power or expected sample size.

The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.

Back to the full JSM 2010 program

2010 JSM Online Program Home

For information, contact or phone (888) 231-3473.

If you have questions about the Continuing Education program, please contact the Education Department.