This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.

Abstract Details

Activity Number: 669
Type: Contributed
Date/Time: Thursday, August 5, 2010 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section
Abstract - #309022
Title: A Method to Analyze Area Under the Curves on Sparse Sampling
Author(s): Huajiang Li*+
Companies: Allergan Pharmaceuticals, Inc.
Address: 2525 Dupont Dr, Irvine, CA, 92612,
Keywords: AUC ; Sparse sampling ; ANOVA
Abstract:

The area under the concentration versus time curve (AUC) is one of important parameters in pharmacokinetics. Bailer's method is widely used for testing and estimating AUC in sparse sampling. We proposed an ANOVA based method, which extended Bailer's method in analyzing AUC. Our method is more flexible and generally more powerful than Bailer's method with support of simulation results.


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