This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.

Abstract Details

Activity Number: 409
Type: Contributed
Date/Time: Tuesday, August 3, 2010 : 2:00 PM to 3:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #308952
Title: A Multiplicity Strategy Incorporating Fixed Sequential, Hochberg, and Fallback Procedures
Author(s): Duane Snavely*+ and Kenneth Liu
Companies: Merck & Co., Inc. and Merck & Co., Inc.
Address: 351 N Sumneytown Pike, North Wales, PA, 19454,
Keywords: Multiplicity ; Hochberg ; Fallback

A new drug may be simultaneously developed for two different indications within a patient population. Two sets of hypotheses (one for each indication) within a single study may include evaluation of multiple variables, time points or doses which contribute to the desired claim structure(s) for the new product. If strong type I error control is desired across these indications and factors, a number of multiplicity strategies may be conceived. We consider a combination of Bonferroni, Fixed Sequential, and Hochberg procedures with incorporation of a Fallback procedure to increase the power for the second set of hypotheses that may be related to the indication of less importance or lower power. Simulations are used to demonstrate the type I error control and power implications of such a strategy compared to other viable alternatives.

The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.

Back to the full JSM 2010 program

2010 JSM Online Program Home

For information, contact or phone (888) 231-3473.

If you have questions about the Continuing Education program, please contact the Education Department.