This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
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Activity Number:
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622
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Type:
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Contributed
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Date/Time:
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Thursday, August 5, 2010 : 8:30 AM to 10:20 AM
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Sponsor:
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Biometrics Section
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| Abstract - #308862 |
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Title:
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Calibration in the Continual Reassessment Method for Phase I Clinical Trials
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Author(s):
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Shing M. Lee*+ and Ying Kuen Cheung
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Companies:
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Columbia University and Columbia University
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Address:
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, , ,
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Keywords:
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Dose finding ;
indifference interval ;
prior selection
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Abstract:
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The continual reassessment method is an adaptive model-based design used to estimate the maximum tolerated dose in phase I clinical trials. Asymptotically the method has been shown to select the correct dose, even under model misspecification, given that certain conditions are satisfied. However, in finite sample settings specifying a reasonable model is important. This is generally done through trial and error. We propose new approaches to systematically calibrate the continual reassessment method based on the concepts of indifference interval and least informative prior variance. The approaches are compared in the context of two examples. The models selected by the systematic approach are competitive to the models obtained through a time consuming trial and error process. The systematic approaches simplify the model calibration process for the continual reassessment method.
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