This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.

Abstract Details

Activity Number: 121
Type: Topic Contributed
Date/Time: Monday, August 2, 2010 : 8:30 AM to 10:20 AM
Sponsor: Section on Bayesian Statistical Science
Abstract - #308584
Title: Making Phylogenetic Inference Robust to Presence of Convergent Evolution
Author(s): Vladimir Minin*+
Companies: University of Washington
Address: Padelford Hall C-315, Box 354322, Seattle, WA, 98195, USA
Keywords: phylogenetics ; convergent evolution ; likelihood equations
Abstract:

Phylogenetic reconstruction aims at reconstructing evolutionary relationships among observed molecular sequences. It is well known that convergent evolution can drive genetic material to the same state and bias all existing phylogenetic reconstruction estimators. One way to make phylogenetic reconstruction robust to convergent evolution is to exclude nonsynonymous mutations from inference. This exclusion strategy is motivated by the assumption that synonymous mutations are approximately neutral. Currently, only distance-based methods are capable for excluding nonsynonymous mutations from phylogenetic reconstruction. We propose a new phylogenetic estimation criterion, inspired by the likelihood equations under group-based mutational models. We study the behavior of the proposed estimation procedure using simulated and real molecular data.


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