This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.

Abstract Details

Activity Number: 537
Type: Contributed
Date/Time: Wednesday, August 4, 2010 : 10:30 AM to 12:20 PM
Sponsor: Section on Risk Analysis
Abstract - #308581
Title: The Impact of Functional Impairment on the Survival of Patients with Alzheimer's Disease
Author(s): Fuwen Liang*+
Companies: MD Anderson Cancer Center
Address: 1155 Pressler, Houston, TX, 77030,
Keywords: Alzheimer's disease ; Survival ; Time-dependent ; Multistate survival analysis ; Hazard rate

Patients with Alzheimer's disease (AD), typically develop increasing difficulty managing their complex and basic activities of daily living functions (ADL). Yet patients who have impaired complex ADL may die before developing impaired basic ADL. Assessment of ADL is helpful to diagnose AD and to understand progression and survival estimation. It is unclear how time-dependent covariates, such as developments of impaired basic ADL influence changes in a patient's status. The effect of impaired basic ADL, utilizing a multistate survival analysis, was examined to estimate the hazard rate in the first few years taking into account the possibility of impaired basic ADL. No impaired basic ADL and older age at onset of impaired basic ADL were associated with longer survival. The findings suggest that the occurrence and age of impaired basic ADL could be predictors of survival among AD patients.

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