This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.

Abstract Details

Activity Number: 360
Type: Contributed
Date/Time: Tuesday, August 3, 2010 : 10:30 AM to 12:20 PM
Sponsor: Biometrics Section
Abstract - #308563
Title: Stable Gene Expression Index in Integrative Analysis
Author(s): Anna Elizabeth Campain*+ and Jean Yang and Francine Marques and Brian Morris
Companies: University of Sydney and University of Sydney and University of Sydney and University of Sydney
Address: School of Mathematics and Statistics F07, NSW, International, 2006, Australia
Keywords: stability ; microarray ; meta-analysis ; integrative ; gene expression

Public microarray datasets have aided the increase in integrating multiple experiments via meta-analysis. In majority of these studies the new analysis examines the same question as the original studies. We examine statistical issues when the main experimental aim is to integrate datasets with a different experimental foci, i.e. to consider different questions. In particular combining different platforms emphasizing gene selection stability, a problem in most microarray analysis but intensified in integrative analysis. We propose a new stability score based on cross validation to identify stable and robust differentially expressed genes in datasets originally developed for a separate purpose. Our method was applied to research into the polygenic condition, hypertension where the main question studied by the scientific investigator was not previously addressed in the original experiments.

The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.

Back to the full JSM 2010 program

2010 JSM Online Program Home

For information, contact or phone (888) 231-3473.

If you have questions about the Continuing Education program, please contact the Education Department.