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Abstract Details

Abstract - #308377
Title: WITHDRAWN: Bayesian Methods in Combination Drug Studies: A Performance Analysis
Author(s): Peiqi Zhai
Keywords: Combination Index, Bayesian, Logistic Regression, Power, Error.

One prevalent goal within clinical trials is to determine whether or not two drugs interact when applied in combination. Holt, Stamey, Seaman, and Young (2008) applied Bayesian analysis and proposed a min test for drug interaction, assuming that non-interaction is modeled by statistical independence. The methods discussed by Holt, Stamey, Seaman and Young were specifically targeted to fixed-dose combination studies that involve binary response data. The authors provided a limited comparison of the Type I error and power of the two procedures using Monte Carlo simulation. This thesis extends the study of Holt et al. (2008) using different prior structures for the min test to study the performance of Bayesian analysis in drug studies.

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