This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
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Activity Number:
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408
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Type:
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Contributed
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Date/Time:
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Tuesday, August 3, 2010 : 2:00 PM to 3:50 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #308268 |
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Title:
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Overall FDR Control in a Two-Stage Adaptive Design
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Author(s):
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Jingjing Chen*+ and Sanat K. Sarkar
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Companies:
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Temple University and Temple University
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Address:
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1024 clark hill dr., eagleville, PA, 19403,
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Keywords:
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FDR ;
adaptive design
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Abstract:
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There are many available statistical methods for adaptive designs, among which overall FWER is controlled via either combination function approach or conditional power approach. Rather than controlling the FWER, we propose a method to control the overall FDR in a two-stage adaptive design. Explicit formulas for the overall FDR and FDR estimate in a two-stage adaptive design based on various combination functions are derived.
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