This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.

Abstract Details

Activity Number: 257
Type: Contributed
Date/Time: Monday, August 2, 2010 : 2:00 PM to 3:50 PM
Sponsor: Section on Statistics in Epidemiology
Abstract - #308153
Title: New Developments in Variance Component Models for Disentangling Maternal Genetic and Environmental Effects in Pedigree Analysis
Author(s): Jin Jin Zhou*+ and Kenneth Lange and Christina Palmer and Janet Suzanne Sinsheimer
Companies: University of California, Los Angeles and University of California, Los Angeles and University of California, Los Angeles and University of California, Los Angeles
Address: Department of Biomathematics, UCLA Medical Center, Los Angeles, CA, 90095,
Keywords: Variance component model ; Asymptotic theory ; Maternal effects

How to disentangle maternal inherited effects, prenatal and postnatal environment effects is an important problem in human genetic research. Studying individuals conceived by assisted reproductive technologies (ART) and their families provides an approach. Current analyses with ART families are limited to models with only fixed effects. Improved study designs and statistical methods need to be developed. We present a more general model where genetic and environmental effects are incorporated as mean or variance components depending on available data. Our model is an extension of the variance component model used in pedigree analysis. It is flexible and handles missing data. Through simulations and asymptotic theory, we tested the statistical properties of our method and evaluated its robustness to model misspecification.

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