This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.

Abstract Details

Activity Number: 512
Type: Contributed
Date/Time: Wednesday, August 4, 2010 : 10:30 AM to 12:20 PM
Sponsor: Biometrics Section
Abstract - #307931
Title: Testing Clonality of Three and More Tumors Using Their Loss of Heterozygosity Profiles
Author(s): Irina Ostrovnaya*+ and Colin Begg
Companies: Memorial Sloan-Kettering Cancer Center and Memorial Sloan-Kettering Cancer Center
Address: 307 E. 63rd str 3rd floor, New york, NY, 10021,
Keywords: clonality ; LOH ; metastasis ; tumors ; independence

Cancer patients often develop multiple malignancies that may be either metastatic spread of a previous cancer or new primary cancers. This distinction is of considerable clinical and biological significance. If diagnosis cannot be made easily on the basis of pathology review, the patterns of somatic mutations in the tumors can be compared. Previously we developed statistical methods for testing clonality of two tumors using their loss of heterozygosity (LOH) profiles at several candidate markers. In this work I will discuss how to extend these methods to three and more malignancies from the same patient. Non-parametric and parametric methods will be considered, and I will present the results of simulation studies.

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