This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
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Activity Number:
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256
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Type:
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Contributed
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Date/Time:
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Monday, August 2, 2010 : 2:00 PM to 3:50 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #307600 |
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Title:
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Calculating an Exact p-Value for a Noninferiority Test on Matched Pair Data
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Author(s):
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Jennifer E. Hamer-Maansson*+
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Companies:
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AstraZeneca
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Address:
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1800 Concord Pike, Wilmington, DE, 19810,
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Keywords:
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non-inferiority ;
crossover ;
McNemar ;
matched ;
pair
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Abstract:
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When testing matched pair data with binary responses for equivalence, one can use a McNemar's test to calculate the p-value. When matched pair data was tested for non-inferiority, the McNemar's test needed to be modified. Using the method presented in Sidik's paper (Statistics in Medicine 2003), a SAS program was created to calculate an exact p-value for a non-inferiority test. The program was then applied to two clinical trials with a 2x2 crossover design to compare a test treatment with a reference treatment for non-inferiority in terms select adverse events.
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The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
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