This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
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Activity Number:
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60
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Type:
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Topic Contributed
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Date/Time:
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Sunday, August 1, 2010 : 4:00 PM to 5:50 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #307495 |
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Title:
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Bayesian Adaptive Designs for Dose Escalation Studies
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Author(s):
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Anna Elizabeth McGlothlin*+
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Companies:
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Eli Lilly and Company
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Address:
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Lilly Corportae Center, Indianapolis, IN, 46285,
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Keywords:
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MTD ;
Bayesian ;
Simulation ;
CRM ;
Oncology ;
Clinical Trial
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Abstract:
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Dose escalation designs are used in early phase oncology clinical development with the intent of identifying the maximum tolerated dose(MTD). Model-based approaches such as the Continual Reassessment Method (CRM) offer benefits over traditional designs by fully leveraging all available information. This presentation will discuss various Bayesian adaptive designs for dose escalation, including the CRM and its modifications. Simulation results will be presented to demonstrate the operating characteristics of these designs. An application from the results will also be presented.
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The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
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