This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.

Abstract Details

Activity Number: 591
Type: Contributed
Date/Time: Wednesday, August 4, 2010 : 2:00 PM to 3:50 PM
Sponsor: Section on Statistics and the Environment
Abstract - #307390
Title: Modification by Frailty Status of the Respiratory Health Effects of Air Pollution in Older Adults
Author(s): Sandrah P. Eckel*+ and Thomas Louis and Karen Bandeen-Roche and Paulo H. Chaves and Helene G. Margolis and Linda P. Fried
Companies: University of Southern California and Johns Hopkins Bloomberg School of Public Health and Johns Hopkins Bloomberg School of Public Health and Johns Hopkins Bloomberg School of Public Health and University of California, Davis and Columbia University Mailman School of Public Health
Address: 1540 Alcazar Street, CHP-220, MC-9011, Los Angeles, CA, 90089-9011,
Keywords: effect modification ; mixed effects models ; elderly ; interaction ; longitudinal data anlaysis ; gerontologic frailty

To enhance our understanding of older adult susceptibility, we investigated whether frailty (a measure of health status in older adults) modifies the effects of air pollution on lung function. We used longitudinal data on the Cardiovascular Health Study (CHS) cohort and monthly average ambient air pollution levels from the CHS Environmental Factors Ancillary Study, interpolated to participant residences. We examined sub-acute and chronic effects by relating time-varying individual-level exposure (O3 or PM10) to a time-varying health outcome (lung function as measured by FEV1 or FVC), emphasizing effect modification by frailty status history. For chronic effects, we used cumulative summaries of exposure (analogous to pack years smoked) and frailty status, and found evidence of increased air pollution-related decline in FVC amongst participants with a longer history of frailty.

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