This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.

Abstract Details

Activity Number: 115
Type: Topic Contributed
Date/Time: Monday, August 2, 2010 : 8:30 AM to 10:20 AM
Sponsor: Biopharmaceutical Section
Abstract - #307181
Title: Adaptive Factorial Designs for Combination Therapy in Oncology
Author(s): Donald Arthur Berry*+
Companies: MD Anderson Cancer Center
Address: 1515 Holcombe Blvd., Houston, TX, 77030,
Keywords: Adaptive design ; Adaptive randomization ; Factorial designs ; Combination therapy ; Seamless phase I/II trials
Abstract:

I will describe a Bayesian approach to adaptive randomization in phase II oncology trials, both theory and practice. I will apply these ideas to factorial designs in the early disease setting, including seamless phase I/II trials that address both toxicity and efficacy in the context of combination therapies. Treatment combinations (including single agents) that are not performing well get assigned fewer patients and are eventually dropped. I will describe some of our experiences at M.D. Anderson Cancer Center with these types of designs, including in leukemia and breast cancer.


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