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Abstract Details

Activity Number: 257
Type: Contributed
Date/Time: Monday, August 2, 2010 : 2:00 PM to 3:50 PM
Sponsor: Section on Statistics in Epidemiology
Abstract - #307169
Title: Interactive Effects of Alcohol and Tobacco on Head and Neck Cancer: A Visualization Using Bivariate Splines
Author(s): Jennifer JinJin Clark*+ and Andrew Olshan and Amy H. Herring
Companies: The University of North Carolina at Chapel Hill and The University of North Carolina at Chapel Hill and The University of North Carolina at Chapel Hill
Address: 439 Summerwalk Circle, Chapel Hill, NC, 27517,
Keywords: bivariate splines ; logistic regression ; head and neck cancer

We analyzed large population-based data of squamous cell carcinoma of the head and neck (SCCHN) across 46 North Carolina counties. An unconditional logistic regression was run first to get ORs for association between cancer and exposure; we then ran comparable bivariate spline models to further explore and provide visual aid for alcohol/tobacco interactions as well as to examine the assumption of homogenous risk within various alcohol and tobacco categories used in the logistic regression. Plots of bivariate splines confirmed an interactive effect of some alcoholic beverages and tobacco on SCCHN. There were slight differences in risk when displaying the spline plots by their categorical versions. Furthermore, the spline model tended to estimate ORs that were higher for wine, lower for liquor and equivalent for beer when compared to results from the logistic regression.

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