This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.

Abstract Details

Activity Number: 256
Type: Contributed
Date/Time: Monday, August 2, 2010 : 2:00 PM to 3:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #306981
Title: Correcting an Incorrect Statistical Practice in Pharmacokinetics and Related Fields
Author(s): Jingyuan Wang*+
Companies: Millennium Pharmaceuticals, Inc.
Address: , Cambridge, MA, 02139,
Keywords: pharmacokinetics ; renew process ; compartment model

Mean residence time(MRT) is a common parameter used in pharmacokinetics to describe the amount of time a drug stays in the body. The current practice is to use a probability distribution proportional to drug concentration to estimate MRT. This practice is mathematically incorrect. Correct methods for both one-compartment and two-compartment models will be presented. The new methods are rigorously derived using some simple differential equations and a little bit of results from renew process.

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