This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.

Abstract Details

Activity Number: 256
Type: Contributed
Date/Time: Monday, August 2, 2010 : 2:00 PM to 3:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #306968
Title: Establishing Sample Size in Clinical Trials Having Multiple Hypotheses
Author(s): Alan Barry Davis*+ and Mary M. Poole and Young Kim
Companies: Pharmanet Development Group, Inc. and Pharmanet Development Group, Inc. and Pharmanet Development Group, Inc.
Address: 6700 Linda Lake Dr., Charlotte, NC, 28215,
Keywords: power ; three-arm clinical trial ; equivalence ; superiority

Many clinical trials have as their objective the rejection of one or more null hypothesis. A clinical trial having k>2 groups can require significance of multiple pre-planned comparisons in order to meet a specific objective. The probability of reaching this objective, or Power, is the probability that a hypothetical alternative to the null hypothesis falls within the region of rejection determined by the joint comparisons. As an example, a three-group parallel trial is considered, in which each subject is to be evaluated as a treatment success or failure. Subjects in group one will receive a new, or test, product; group two subjects will receive a standard reference product, and subjects in group three will receive a placebo.

This poster will present the power of rejecting the individual and joint comparisons as a function of sample size and treatment-group success rates.

The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.

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