This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.

Abstract Details

Activity Number: 670
Type: Contributed
Date/Time: Thursday, August 5, 2010 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section
Abstract - #306919
Title: CTDesignExplorer: An Action Queue--Based Open-Source Simulation Experiment Platform for Evaluating Clinical Trial Designs
Author(s): Yuanyuan Wang*+ and Roger Day and Daniel Normolle
Companies: University of Pittsburgh and University of Pittsburgh and University of Pittsburgh
Address: , , ,
Keywords: Open-source ; Clinical trial simulation ; Clinical trial design ; S4 classes and methods ; Interoperability
Abstract:

Clinical trial (CT) simulation is used to improve the efficiency and accuracy of drug development. Inspired by the success of open-source software development projects, we are building CTDesignExplorer - an open-source simulation experiment platform utilizing the power of distributed design expertise, development talent and peer review of code. The code base relies on S4 classes and methods within R. Design, baseline characteristic model, population model, outcome model, and evaluation criterion are five key object types. An action queue-based approach allows for complex decision making at the patient or CT level. The exchange of common data elements provides interoperability among the objects. Extensibility, reuse and sharing come from the class/method architecture, together with automatic object and documentation discovery mechanisms.


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