This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.

Abstract Details

Activity Number: 128
Type: Contributed
Date/Time: Monday, August 2, 2010 : 8:30 AM to 10:20 AM
Sponsor: Biopharmaceutical Section
Abstract - #306767
Title: EWOC Online: A Novel Web Application for Computing a Bayesian Phase I Design Method for Dose-Finding with Escalation with Overdose Control
Author(s): Dror Berel*+ and Andre Rogatko
Companies: Cedars-Sinai Medical Center and Oschin Comprehensive Cancer Institute
Address: 116 North Robertson, #500., los angeles, CA, 90048,
Keywords: EWOC ; Bayesian ; R ; Apache ; Phase I Clinical Trials ; cancer

EWOC is a Bayesian method for selecting dose levels in Cancer Phase I Clinical Trials while controlling the probability of exceeding the maximum tolerated dose. Earlier implementation of EWOC is available as stand-alone Windows software, programmed in FORTRAN. The present implementation uses a novel "cloud computing" environment, and can be accessed as a web application, running R code on Apache web server. Using an adaptive dose escalation scheme, based on a parametric quantal response model, EWOC maximize the tolerated dose as fast as possible, subject to constraint that the predicted probability of assigning doses higher than the maximum tolerated dose, is equal to a specified value. Rapache is a module for the Apache web server, which allows embedding of R scripts in a webpage, connecting the HTTPD to R. MCMC methods are run through the BUGS project, accessed and controlled via R.

The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.

Back to the full JSM 2010 program

2010 JSM Online Program Home

For information, contact or phone (888) 231-3473.

If you have questions about the Continuing Education program, please contact the Education Department.