This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
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Activity Number:
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395
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Type:
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Topic Contributed
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Date/Time:
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Tuesday, August 3, 2010 : 2:00 PM to 3:50 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #306734 |
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Title:
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Principal Stratification Methods for Evaluating Immunological Surrogate Endpoints in a Vaccine Efficacy Trial
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Author(s):
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Peter Gilbert*+
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Companies:
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Fred Hutchinson Cancer Research Center
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Address:
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1100 Fairview AVE N PO Box 19024, Seattle, WA, 98109, USA
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Keywords:
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surrogate endpoint ;
clinical trial ;
vaccine ;
biomarker ;
survival analysis ;
causal inference
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Abstract:
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This talk presents methods for evaluating an immunological biomarker(s) as a surrogate of protection in a placebo-controlled vaccine efficacy trial. The methods evaluate the biomarker as a potential surrogate endpoint for a right-censored primary endpoint. The methods require either baseline predictors of the immunological biomarker in a standard placebo controlled study, or, alternatively, a one-way crossover design wherein some placebo subjects are vaccinated and have their immunological biomarker measured. The methods can be used to compare biomarkers or to evaluate the value of additional biomarkers to improve surrogacy.
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The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
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