This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
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Activity Number:
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504
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Type:
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Topic Contributed
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Date/Time:
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Wednesday, August 4, 2010 : 10:30 AM to 12:20 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #306717 |
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Title:
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On Two-Stage Adaptive Design
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Author(s):
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Gang Li*+ and Yining Wang and Weichung J. Shih
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Companies:
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Johnson & Johnson and Johnson & Johnson and University of Medicine and Dentistry of New Jersey
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Address:
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920 Route 202 South, Raitan, NJ, 08869,
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Keywords:
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adaptive design ;
likelihood ratio test ;
admissibility
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Abstract:
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In two-stage adaptive design, the second stage sample size depends on the observed data from the first stage. The literature focus on the control of the Type I error rate and pays little attention the adequate initial sample size. In this research, the specification of initial sample size is explored. The efficiency of two procedures are evaluated: the likelihood procedure and the fix-weight procedure. The power loss of the fix-weight procedure is studied. The likelihood procedure is proven to be in a complete class, while the fix-weight procedure is inadmissible. Power comparisons are also performed through simulation.
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