This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.

Abstract Details

Activity Number: 226
Type: Topic Contributed
Date/Time: Monday, August 2, 2010 : 2:00 PM to 3:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #306705
Title: Partition Testing for Efficacy with Multiple Endpoints, with Software
Author(s): Jason C. Hsu*+ and Yi Liu
Companies: The Ohio State University and Millennium Pharmaceuticals, Inc.
Address: , , ,
Keywords: Multiple endpoints ; primary endpoints ; secondary endpoints ; Decision Path Principle ; Partition Testing ; software
Abstract:

When there are primary and secondary endpoints, efficacy in a secondary endpoint is only relevant if efficacy in the primary endpoint has been shown. Using the partitioning principle, Liu and Hsu (2009 JASA) proposed the Decision Path Principle to test for efficacy in primary and secondary endpoints. The number of path-respecting partition hypotheses is far fewer than those tested by Gatekeeping methods. Our method takes joint distribution into account, and is more powerful than those that do not. Our DoseEndpoints software implements Endpoint Prioritization: If efficacy in higher ordered endpoint is shown for all doses, then testing proceeds as if the next highest ordered endpoint were one order higher. DoseEndpints also implements Dose Multiplicity Adjustment: If a dose is shown to be efficacious in all endpoints, then that dose should no longer be included in multiplicity adjustment.


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