This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
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Activity Number:
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225
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Type:
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Topic Contributed
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Date/Time:
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Monday, August 2, 2010 : 2:00 PM to 3:50 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #306384 |
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Title:
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Statistical Design for a Small Serial Dilution Series
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Author(s):
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Daniel Zelterman*+
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Companies:
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Yale University
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Address:
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333 Cedar Street PO Box 208034 , New Haven, CT, 06520-8034,
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Keywords:
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experimental design ;
entropy ;
HIV infection ;
syringe exchange ;
harm reduction ;
binomial distribution
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Abstract:
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We describe statistical plans for a serial dilution series designed to detect and estimate the number of viral particles in a solution. The design addresses a problem when a very limited number of aliquots are available for proliferation. A gamma prior distribution on the number of viral particles allows us to describe the marginal probability distribution of all experimental outcomes. We examine a design that minimizes the expected reciprocal information and compare this with the maximum entropy design. We argue that the maximum entropy design is more useful from the point of view of the laboratory technician. The problem and design are motivated by our study of the viability of HIV in syringes and other equipment that might mediate blood-borne viral transmission.
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The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
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