This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
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Activity Number:
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564
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Type:
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Topic Contributed
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Date/Time:
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Wednesday, August 4, 2010 : 2:00 PM to 3:50 PM
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Sponsor:
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Biometrics Section
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| Abstract - #306376 |
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Title:
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Robust Transmission Disequilibrium Test for Family Trio Design
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Author(s):
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Min Yuan and Yaning Yang and Xin Tian and Gang Zheng*+
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Companies:
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Fudan University, China and University of Science and Technology of China and National Institutes of Health and National Institutes of Health
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Address:
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Office of Biostatistics Research, DPPS, Bethesda, MD, 20892, USA
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Keywords:
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adaptive ;
genetic model selection ;
efficiency robustness ;
HWD ;
MAX ;
TDT
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Abstract:
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The TDT is often used to detect genetic association using trios. It is optimal for an additive genetic model. Other TDT-type tests optimal for other genetic models (e.g., recessive and dominant models) have also been studied. TDT-type tests have high efficiency when the genetic model is known or correctly specified, but may lose power if the model is misspecified. Hence tests that are robust to genetic model misspecification yet efficient are preferred. Constrained likelihood ratio test (CLRT) and MAX-type test have been shown to be efficiency robust. In this talk, we propose new efficiency robust procedures, which incorporate Hardy-Weinberg disequilibrium with genetic model selection.
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The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
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