This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.

Abstract Details

Activity Number: 100
Type: Invited
Date/Time: Monday, August 2, 2010 : 8:30 AM to 10:20 AM
Sponsor: Section on Statistics in Epidemiology
Abstract - #306288
Title: Controlling Confounding in (Genetic) Case-Control Studies Using the Stratification Score
Author(s): Glen Satten*+ and Andrew Allen
Companies: CDC and Duke University
Address: , , ,
Keywords: Stratification score ; Confounding ; Association ; Genetics ; Propensity score ; Case-control study

We recently introduced the stratification score, which is the probability of disease given potential confounders, as a method for control of confounding by population stratification in genetic association studies. We showed that tests using data post-stratified on the stratification score are appropriately sized and have good power to detect association in the presence of confounding. Here we consider the theoretical basis for the stratification score, and show how standardization based on the stratification score can lead to estimates of the difference in exposure (or allele frequency, in the genetic case) that would have been seen if cases and controls had the same distribution of confounding covariables. Real data and simulation studies are used as illustrations.

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