This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.

Abstract Details

Activity Number: 386
Type: Invited
Date/Time: Tuesday, August 3, 2010 : 2:00 PM to 3:50 PM
Sponsor: Statisticians in the Pharmaceutical Industry
Abstract - #306177
Title: Optimal Designs for Pharmacokinetic Models
Author(s): Holger Dette*+ and Tim Holland-Letz
Companies: Ruhr-Universität Bochum and Ruhr-Universität Bochum
Address: Universitätsstr. 150, Bochum, International, 44795, Germany
Keywords: random effects ; optimal design ; pharmacokinetics
Abstract:

In this talk we explain a geometric method for constructing optimal designs for pharmacokinetic models In particular we generalize a classical result of Elfving (1952) and discuss important applications in the construction of optimal designs for random effect models with correlated observations, which have found considerable attention in the receent literature on pharmacokinetics. The results are illustrated in several population models.

References: H.Dette, T. Holland-Letz (2009). A geometric characterization of c-optimal designs for heteroscedastic regression. To appear in: Annals of Statistics.


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