This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.

Abstract Details

Activity Number: 487
Type: Invited
Date/Time: Wednesday, August 4, 2010 : 10:30 AM to 12:20 PM
Sponsor: ENAR
Abstract - #306148
Title: Statistics, Technology, Epigenomics, and Our Future
Author(s): Rebecca W. Doerge*+ and Paul Auer
Companies: Purdue University and Purdue University
Address: 150 North University Street, West Lafayette, IN, 47907,
Keywords: Next-gen Sequencing ; Solexa ; SOLiD ; differential expression ; epigenomics ; genomics

This is an exciting and influential time for the field of Statistics in science. Technological advances in genetic, genomic, and the other 'omic sciences are providing large amounts of complex data that are presenting a number of challenges for the biological community. Many of these challenges are deeply rooted statistical issues that involve experimental design. Focusing on next-generation sequencing technology we will introduce the technology and discuss issues of randomization, blocking, and replication. Applications of next-generation sequencing for testing differential expression, as well as investigating the roles of DNA and histone modification, and small RNAs, in heterochromatic silencing and transposon control will be presented.

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