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Activity Number:
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277
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Type:
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Contributed
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Date/Time:
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Tuesday, August 4, 2009 : 8:30 AM to 10:20 AM
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Sponsor:
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Biometrics Section
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| Abstract - #304965 |
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Title:
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Covariate-Adjusted Correlation Analysis with Application to FMR1 Premutation Female Carrier Data
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Author(s):
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Damla Senturk*+ and Danh Nguyen
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Companies:
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Penn State University and University of California, Davis
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Address:
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411 Thomas Building, University Park, PA, 16802,
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Keywords:
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Conditional correlation ; Fragile X syndrome ; Semiparametric modeling ; Pearson correlation ; Local method of moments
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Abstract:
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Motivated by molecular data on female premutation carriers of the fragile X mental retardation 1 (FMR1) gene, we present a new method of covariate adjusted correlation analysis to examine the association of messenger RNA (mRNA) and number of CGG repeat expansion in the FMR1 gene. The association between the molecular variables in female carriers needs to adjust for activation ratio (ActRatio), a measure which accounts for the protective effects of one normal X chromosome in females carriers. However, there are inherent uncertainties in the exact effects of ActRatio on the molecular measures of interest. In order to account for these uncertainties, we develop a flexible adjustment that accommodates both additive and multiplicative effects of ActRatio nonparametrically. The results provide independent support for a specific additive and multiplicative adjustment form previously proposed.
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